Less is more. Illustrations of the validity of this mantra in life and clinical medicine are not hard to find. Examples abound in the realm of critical care, such as with mechanical ventilation1 and transfusion targets.2 Perhaps the best example in critical care nephrology is in dose of continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI). Early enthusiasm for the routine use of high-dose CKRT fueled by smaller single-center studies was halted by the publication in 2008 and 2009 of the VA/NIH Acute Renal Failure Trial Network (ATN) and the Randomized Evaluation of Normal vs Augmented Level (RENAL) Replacement Therapy studies.