It is well-established that metabolic changes and autosomal dominant polycystic kidney disease (ADPKD) progression is closely related. Metabolic reprogramming is a key feature of ADPKD, which includes higher glycolysis, abnormal lipid metabolism, and so on.1 However, the detailed association between nutritional status and the loss of kidney function in ADPKD has not been fully investigated in previous studies. We read the article “Nutritional status is associated with preserved kidney function in patients with autosomal dominant polycystic kidney disease” by Lee and colleagues with great interest.