The United States Renal Data System 2022 Annual Data Report (ADR) contains data from medical claims through 2020 and for some end-stage renal disease (ESRD)-related metrics through the first half of 2021. As such, this is the first year in which the wide-ranging effects of the coronavirus disease 2019 (COVID-19) pandemic on the chronic kidney disease (CKD) and ESRD populations can be placed into the full context of the years that preceded its onset. Another important aspect of this year’s ADR is a continued focus on racial, ethnic, and socioeconomic disparities in access to health care and outcomes.