Life expectancy has improved considerably over the past decade and consequently the aging population continues to increase. As one ages, kidney function decreases, as evidenced by the decline in the glomerular filtration rate, owing to nephron loss. The loss of podocytes, the postmitotic cells that line the outermost surface of the glomerulus, is thought to be a contributor to this process. An unmet need exists to understand the molecular mechanism of podocyte aging and develop therapeutic interventions to delay the process of age-related declines in kidney function.