Clinical Factors and Adverse Kidney Outcomes in Children With Antineutrophil Cytoplasmic Antibody–Associated Glomerulonephritis

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are rare disorders in childhood with a variable clinical presentation. Given ANCA vasculitides’ rarity, data informing clinical practice and treatment are mainly based on adult data. The purpose of this study was to characterize clinical characteristics of ANCA-associated glomerulonephritis (AAGN) in childhood to determine factors associated with adverse renal outcome and the requirement for kidney replacement therapy (KRT) across a global study population.