Since the 1970s, the accepted standard of care for children presenting with their first episode of nephrotic syndrome has been a course of oral prednisone comprising 60 mg/m2 (2 mg/kg) daily for 4 weeks followed by 40 mg/m2 (1.5 mg/kg) on alternate days for 4 weeks with or without a tapering dose.1,2 A meta-analysis of randomized controlled trials (RCTs) in 2007 concluded that prednisone treatment for ≥3 months compared with 2 months reduced the risk of relapse at 12-24 months.3 However some included studies were at high risk of bias, which, on average, leads to an overestimation of the treatment effect observed.