For 2 years, the coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc on our health systems. The pandemic has adversely impacted the transplant community—from organ procurement to outcomes. In the United States, the development and free distribution of several effective vaccines has not been the panacea that we had hoped for as uptake of COVID-19 vaccines has been mired in controversy. This has led to moral distress among transplant professionals about how to deal with vaccine refusers.