Genome-wide association studies (GWAS) provide a basis for the role of genetic variation in determining kidney function. Modern GWAS are conducted on a massive scale and have contributed to a growing list of single-nucleotide variants associated with estimated glomerular filtration rate (eGFR), blood pressure, and other kidney-related traits.1-3 A major challenge in translating these discoveries into biological insight is assigning function and context to the ∼90% of variants located in non-coding regions.