Underscoring the Case for Better Markers of Kidney Injury in Deceased Donors
Deceased organ donors frequently have acute kidney injury (AKI), which results in elevated terminal creatinine. The elevated terminal creatinine, rather than the baseline creatinine, is used to calculate the Kidney Donor Profile Index (KDPI), which results in a higher KDPI percentile when a donor experiences AKI. This high KDPI further disadvantages organs with AKI, which are already at a disproportionately increased risk of discard secondary to concerns for delayed graft function (DGF) and allograft failure in recipients.
