There is a renewed interest in home dialysis since the announcement of the Advancing American Kidney Health Initiative, which aims to achieve 80% of incident patients with kidney failure receiving home-based therapy or a kidney transplant by 2025 in the United States. Home hemodialysis (HHD) (especially in the form of more frequent hemodialysis) has been associated with multiple clinical advantages such as regression of left ventricular hypertrophy, improvement in blood pressure, normalization of phosphate levels, and reduction in cardiovascular-related hospitalization.