Even though safe and effective vaccines have been developed for SARS-CoV-2, variants of concern continue to emerge.1,2 We present a comparison of 2 COVID-19 waves in 2 hemodialysis facilities. Patients in 1 hemodialysis facility (“wave 1”) were infected by nonvariant SARS-CoV-2 between July and October 2020. Patients from the second facility (“wave 2”) became ill between December 28, 2020, and January 10, 2021 and were infected by a variant SARS-CoV-2 from the B.1.362 lineage, termed IVUI-L452R (Israeli variant under investigation with L452R mutation).