Incidence and Predictors of CKD and Estimated GFR Decline in Patients Receiving Immune Checkpoint Inhibitors
First approved in 2010 for treatment of metastatic melanoma, immune checkpoint inhibitors (ICIs) are now approved for more than 17 cancer types, and it is estimated that 1 in 3 patients with cancer now qualify for ICIs.1 ICIs remove key regulators of T-cell function to unleash antitumor effects, but T-cell disinhibition can also cause immune-related adverse events in up to 60%-85% of patients.2 Though the epidemiology of ICI-induced acute kidney injury has been well characterized,3-5 there is extremely limited data on the long-term toxicities of ICIs.
