Kidney disease is a global epidemic, and people living with chronic kidney disease (CKD) are among the highest risk groups for cardiovascular mortality. For this reason, improved understanding of the development and progression of CKD, as well as its cardiovascular complications, is urgently needed. Observational studies have demonstrated that while females have a higher prevalence of CKD overall, they may be protected from CKD progression compared to males,1 although this may be limited to the premenopausal years.