Comparing Multiple-Biomarker Panels for Estimating GFR With Estimating Equations Without a Coefficient Distinguishing Black Individuals From Persons of Other Groups

Inker et al1 propose a new estimated glomerular filtration rate (GFR) equation integrating a panel of biomarkers (creatinine, cystatin C, β-trace protein, and β2-microglubulin) as an alternative to the creatinine-based CKD-EPI equation (CKD-EPIcr). This equation—the most used GFR-estimating equation—has recently been criticized for applying a discriminative term based on self-reported race.2 Inker et al convincingly demonstrated that their triple marker–based equation performs better than the CKD-EPI equation based on cystatin C only, a race-independent estimator.