Patients with early mild or asymptomatic coronavirus disease 2019 (COVID-19) who require intense immunosuppression for underlying immune-mediated diseases pose a dilemma to physicians. In severe COVID-19, organ salvaging measures may not seem a top priority. However, because 80% of COVID-19 illnesses are mild, lasting about a week, starting or delaying intense immunosuppression in early mild COVID-19 and active glomerular diseases should be based on informed decision making.