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MicroRNA-196a/b Mitigate Renal Fibrosis by Targeting TGF-{beta} Receptor 2

Organ-specific microRNAs have essential roles in...

Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4

Within the kidney, the (pro)renin receptor (PRR) is...

EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption

Nephrogenic diabetes insipidus (NDI) is caused by...

Blockade of Orai1 Store-Operated Calcium Entry Protects against Renal Fibrosis

Evidence supports an important role of Ca2+...

Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease

Novel therapies in autosomal dominant polycystic kidney...

Prorenin Receptor, a Necessary Component in Urine Concentration Mechanism

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Sex Differences in Renal Proximal Tubular Cell Homeostasis

Studies in human patients and animals have revealed sex-...

Polymorphisms in {alpha}-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux

The contribution of genetic variation to urinary tract...

Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD

The association between proton pump inhibitors (PPI) use...

Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese

An intronic variant at the complement factor H (...

Adjusting the 17{beta}-Estradiol-to-Androgen Ratio Ameliorates Diabetic Nephropathy

Diabetes is manifested predominantly in males in...

Combined Assessment of Phospholipase A2 Receptor Autoantibodies and Glomerular Deposits in Membranous Nephropathy

Serum phospholipase A2 receptor antibodies (SAbs) and...

Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort

Two common missense variants in APOL1 (G1 and G2...

Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis

Tubulointerstitial nephritis is a common cause of kidney...

Gene Editing: Powerful New Tools for Nephrology Research and Therapy

Biologic research is experiencing a transformation...

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