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Renin-Angiotensin-Aldosterone System Inhibition Increases Podocyte Derivation from Cells of Renin Lineage

Because adult podocytes cannot proliferate and are...

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease

APOL1 risk variants are associated with kidney...

Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD),...

Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection

Belatacept is a biologic that targets CD80/86 and...

Immune-Regulatory Molecule CD69 Controls Peritoneal Fibrosis

Patients with ESRD undergoing peritoneal dialysis...

A FANCD2/FANCI-Associated Nuclease 1-Knockout Model Develops Karyomegalic Interstitial Nephritis

Karyomegalic interstitial nephritis (KIN) is a chronic...

Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx

Diabetic nephropathy (DN) is the leading cause of CKD in...

Phospholipase A2 Receptor-Related Membranous Nephropathy and Mannan-Binding Lectin Deficiency

Most patients with idiopathic membranous nephropathy (...

Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context

Patients with autosomal dominant polycystic kidney...

Coronary Revascularization in Patients with CKD Stage 5D: Pragmatic Considerations

Coronary revascularization decisions for patients with...

Acidosis and Urinary Calcium Excretion: Insights from Genetic Disorders

Metabolic acidosis is associated with increased urinary...

Predicting the Functionality and Form of a Dialysis Fistula

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Preserving Residual Kidney Function in Hemodialysis Patients--Back in the Spotlight

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TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease

The identification of the cellular origins of...

Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function

Aberrant activation of mechanistic target of rapamycin...

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