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Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

Interstitial fibrosis is an important contributor to...

Targeting mTOR Signaling Can Prevent the Progression of FSGS

Mammalian target of rapamycin (mTOR) signaling is...

Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1

IgA nephropathy (IgAN), an important cause of kidney...

Global Cardiovascular and Renal Outcomes of Reduced GFR

The burden of premature death and health loss from ESRD...

Sickle Cell Trait and the Risk of ESRD in Blacks

Blacks, compared with whites, have an increased risk of...

Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography

The mucoprotein uromodulin is the most abundant protein...

Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States

Increased urine albumin excretion is highly prevalent in...

Cell-Free DNA and Active Rejection in Kidney Allografts

Histologic analysis of the allograft biopsy specimen is...

Growth Differentiation Factor-15 and Risk of CKD Progression

Growth differentiation factor–15 (GDF-15) is a member of...

Apixaban Pharmacokinetics at Steady State in Hemodialysis Patients

It is unclear whether warfarin is protective or harmful...

Comparing Outcomes between Antibody Induction Therapies in Kidney Transplantation

Kidney transplant recipients often receive antibody...

The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis

Bacterial peritonitis remains the main cause of...

IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis

IL-36 cytokines are proinflammatory and have an...

Inhibition of Reticulon-1A-Mediated Endoplasmic Reticulum Stress in Early AKI Attenuates Renal Fibrosis Development

Several animal studies have shown an important role for...

Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates

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