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ApoL1 Overexpression Drives Variant-Independent Cytotoxicity

Coding variants in the APOL1 gene are associated...

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation

Collecting ducts make up the distal-most tubular...

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

Tamm–Horsfall protein (THP), also known as uromodulin,...

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning

The nephron is the functional unit of the kidney, but...

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney

Cellular interactions among nephron, interstitial, and...

Differentiating Primary, Genetic, and Secondary FSGS in Adults: A Clinicopathologic Approach

FSGS describes a renal histologic lesion with diverse...

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis

Human kidney function is underpinned by approximately 1,...

Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion

The epithelial Wolffian duct (WD) inserts into the...

Targeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives

The unique contributions of memory B cells and plasma...

Salt-Losing Tubulopathies in Children: Whats New, Whats Controversial?

Renal tubulopathies provide insights into the inner...

The Benefits of Tubular Proteinuria: An Evolutionary Perspective

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Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction

Increased export of transglutaminase-2 (TG2) by tubular...

Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling

In patients with CKD, not only renal but also, nonrenal...

Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation

Albuminuria is a key instigator of tubulointerstitial...

Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury

The IL-33-type 2 innate lymphoid cell (ILC2) axis has an...

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