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Plasma Potassium Determines NCC Abundance in Adult Kidney-Specific {gamma}ENaC Knockout

The amiloride-sensitive epithelial sodium channel (ENaC...

Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury

The IL-33-type 2 innate lymphoid cell (ILC2) axis has an...

Pathogenicity of a Human Laminin {beta}2 Mutation Revealed in Models of Alport Syndrome

Pierson syndrome is a congenital nephrotic syndrome with...

CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis

The importance of the kidney distal convoluted tubule (...

Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction

Increased export of transglutaminase-2 (TG2) by tubular...

ApoL1 Overexpression Drives Variant-Independent Cytotoxicity

Coding variants in the APOL1 gene are associated...

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation

Collecting ducts make up the distal-most tubular...

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

Tamm–Horsfall protein (THP), also known as uromodulin,...

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning

The nephron is the functional unit of the kidney, but...

Targeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives

The unique contributions of memory B cells and plasma...

Salt-Losing Tubulopathies in Children: Whats New, Whats Controversial?

Renal tubulopathies provide insights into the inner...

The UMOD Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease

The identification of genetic factors associated with...

Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling

In patients with CKD, not only renal but also, nonrenal...

The Era of Human Developmental Nephrology

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Evolution and Kidney Development: A Rosetta Stone for Nephrology

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