Histopathologic Correlates of Kidney Function: Insights From Nephrectomy Specimens

Existing datasets correlating kidney histopathologic findings with renal function have low proportions of elderly patients (and those with a family history of end-stage kidney disease are over-represented) which limits their generalizability. Our objective was to use non-neoplastic tissue from nephrectomy specimens to examine the association between the degree of histopathologic changes and estimated glomerular filtration rate (eGFR), and to determine if the association differed by age.